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But retatrutide adds a third receptor to the mix, which may explain the difference in weight loss results seen in trials so far

In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems

There is an urgent need for rigorously designed, large-scale, randomized, placebo-controlled trials that evaluate diverse probiotic formulations within well-defined patient cohorts to generate definitive and reproducible outcomes (280, 453)

SW conducted the literature review and drafted the manuscript

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Unlike approved drugs, they havent undergone the rigorous testing required to understand their safety profile in humans